Matthew I Arhewoh1,
Sylvester O Eraga1
,
Philip F Builders2,
Uchenna A Uduh1
For correspondence:- Sylvester Eraga Email: eragaso@uniben.edu Tel: +234-8030884928
Published: 30 December 2014
Citation: Arhewoh MI, Eraga SO, Builders PF, Uduh UA. Snail Mucin-Based Formulation of Ibuprofen for Transdermal Delivery. J Sci Pract Pharm 2014; 1(1):31-36 doi: 10.47227/jsppharm.v1i1.7
© 2014 The author(s).
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Purpose: To evaluate the bioadhesion properties and drug release profile of mucin-based ibuprofen (IBF) transdermal patches.
Methods: Mucin was extracted from the giant African snail, Archachatina maginata, by differential precipitation with acetone and alum. Various batches of IBF loaded transdermal film patches were prepared with the precipitated mucin and varying volumes (0.2, 0.5, and 1 mL) of polyethylene glycol (PEG) as plasticizer. Prepared patches were evaluated for weight uniformity, patch thickness, folding endurance, moisture content and uptake, bioadhesion, drug content, in-vitro and ex-vivo (skin permeation) release profiles.
Results: Extraction of mucin with acetone and alum gave a mucin yield of 0.1 and 0.08% w/w, respectively. DSC analysis showed no interaction between the drug and excipients. There was an increase in the weight, thickness, folding endurance, drug content, moisture content and uptake with increasing volumes of PEG incorporated in the formulated patches. Moisture content and uptake values of patches made from mucin precipitated with alum decreased from 17 and 80 % with increasing PEG volumes to 7.7 and 50 %, respectively. All the patches showed bioadhesion values between 0.87 g/sec and 1.46 g/sec and in-vitro drug release gave 78 % after 2 h while ex-vivo diffusion across treated rat skin reached 74 % after 12 h.
Conclusion: Snail mucin showed promise as a transdermal drug delivery base in the formulation of IBF patches because of its bioadhesion property and drug release profile
